Kongera kwandura virusi itera SIDA-1 na bacterium ya Periodontopathic

Ingirabuzimafatizo zanduye zibitse virusi ya VIH-1 virusi ya ADN yinjizwa cyane cyane muri heterochromatine, bigatuma hakomeza kubaho virusi zicecekera.Hypoacetylation ya poroteyine ya histone na histone deacetylase (HDAC) igira uruhare mu kubungabunga ubukererwe bwa VIH-1 mu guhagarika kwanduza virusi.Byongeye kandi, indwara zifata igihe, ziterwa na bagiteri ziterwa na polymicrobial subgingival harimo na Porphyromonas gingivalis, ziri mu ndwara zanduye abantu.Hano turerekana ingaruka za P. gingivalis kuri kwigana VIH-1.Iki gikorwa gishobora gusobanurwa numuco wa bagiteri ndengakamere ariko ntukore kubindi bice bya bagiteri nka fimbriae cyangwa LPS.Twasanze iki gikorwa gitera VIH-1 cyagaruwe mubice bya molekile yo hepfo (<3 kDa) igice cyumuco ndengakamere.Twerekanye kandi ko P. gingivalis itanga aside irike ya butyric, ikora nka inhibitori ikomeye ya HDACs kandi igatera acetylation ya histone.Ubushakashatsi bwa Chromatin immunoprecipitation bwagaragaje ko uruganda rwibanze rurimo HDAC1 na AP-4 rwatandukanijwe na virusi itera sida ya virusi itera SIDA-1 nyuma yo gukangurwa n’umuco wa bagiteri ndengakamere hamwe n’ishyirahamwe rya acetylated histone na RNA polymerase II.Twasanze rero P. gingivalis ishobora gutera virusi ya VIH-1 binyuze mu guhindura chromatine kandi ko aside butyric, imwe muri metabolite ya bagiteri, ari yo nyirabayazana w'izo ngaruka.Ibi bisubizo byerekana ko indwara zifata igihe zishobora kugira uruhare mu kwandura virusi itera SIDA-1 ku bantu banduye kandi zishobora kugira uruhare mu gukwirakwiza virusi.